Re: Amplitube 3
Is the "static noise" heard at all times, or only when you play loud notes? If you only hear this when you play, you probably need to bring your guitar volume down a bit to avoid clipping the sound card input on your computer. (Digital clipping is nasty static - not at all like tube or even transistor clipping.)
Either turn down the volume at your guitar, or turn down the gain if you're going through a pedal.
If that doesn't solve it, a better description of your signal chain would help.