I have never put a BW in a Les Paul (or any other guitar). However - BW's being a 'more refined' Distortion....
Gibson themselves put 500T's in Les Pauls, and I LOVE my Duncan Distortion in my #1 LP. So based on what I have read/heard about the BW, and my knowledge of those other two pickups - not at all! The mids on those pickups brick the crunch and aggression. So for metal - no problems at all.
In Mahogany Single cuts, and playing general metal-styles, I use and love both the Distortion, and the Custom. And sometimes a JB.