Re: Can an HSS Strat...
You can do any combination of pickups that is physically workable with switches and control pots. You can hard-mount pups, or rout wood to fit others.... you can do anything you want to, so long as you have the ability.
FWIW, I never understood the typical Fender use of normal single coils and a ridiculously hot bridge pickup. Personally, I'd opt for something PAF-like, such as a '59 or '78, that way the pickups blend well when you switch to various positions. At one point, I had a stock Squier single coil, a Tone Zone S in the middle position (not as hot as you'd think) and a 'TB59 in the bridge and it was a great combination. A stock '59 CAN take hi-gain amps or pedals well, if you have to "metalize" your sound.