That question is not really possible to answer until you specify more clearly what two types of pickups you are comparing.
More importantly, the question doesn't make sense theoretically, because DC resistance is not output, and the two pickup designs are quite far apart.
But playing along anyhow...
Many people erroneously use the term "single coils" to refer only to Fender-style single coils, in which the pole pieces themselves are the magnets. However, there are other single coil designs that use the same basic principle as a humbucker: magnet (or magnets) sits below, and the pole pieces are steel temporary magnets that bend the magnetic field toward the strings. E.g. a P90.
Assuming the same strength of magnet/s, and assuming a classic humbucker design (let's say a typical PAF-type construction) and a classic Fender design, then: Even at the same DCR, the humbucker will create more output. This is because pickups with the bar magnet below, and steel pole pieces that bend the field upward, are more sensitive by design than are pickups in which the pole pieces themselves are the pickup magnets.
A better way to think of this point is with old style Mexican Strat pickups. They're basically constructed like mini P90's. Two bar magnets glued on the bottom, steel poles direct then field upward. Make some recordings of the pickup that way. Then go in, chisel the magnets off, tap the steel poles out, and install typical Fender rod magnets of the same magnet type as the original bar magnets. Make another set of recordings. You will see that the original construction of the pickup created more output, even though DCR was identical in both orientations.
Thing is, there is no real-world scenario in which your question would actually come up. DCR is not output, and a pickup of one general design (e.g. an old Strat pickup) can't be directly compared to a pickup of another general design (e.g. a Gibson-style humbucker) in that way.