I have to ask...exactly where or who have you heard this from? I ask, because I'd like to explain to them, in person, what sort of a special idiot jack@$$ they are and suggest they close their trap when they know not that of which they speak.
I can think of reasons why you might not like it given your rig, styles of music you prefer, or perhaps style of playing. But the very simple equation of Custom + J5 Tele (even a Squire) should rock balls.
John 5 plays DiMarzio D-Activiators I believe. Or did. Those are about as hot as a SuperDistortion, meaning a little more chill than a Custom. But they are 11k pups. A little interwebz research also shows pretty flat eq. The Custom likely has less mids. Or more bass and treble, than those.
Tell us more about what you are doing? Feel free to PM me with the name and web location of "Them" who says "This" which you have "Heard."