I am a huge fan of both and have been using both for decades.
Statement: A PAF on Steroids. - and PCP too if you ask me. It is a great all around hard rock heavy metal pickup period, and has more flexibility than that even.
Bass: Big bass, that "Thumps" and chugs great. Bass is tight with a slight rounded quality to it (very slight)
Mids: While scooped relative to the bass and treble, the mids are definitely present. They don't cut like a machete, but they don't get lost either.
Highs: Screaming, cutting ceramic highs, that are honestly very similar / the same as the Distortion.
Output: Hot Hot Hot, but cleans up ok with volume. Lower height can take some heat off and extend the functional range of volume control.
Music: Later Def Leppard, Whitesnake, Iron Maiden, Motley Crue (Feelgood), Metallica (Black)
Guitars: My #1 Dean Cadillac for stage, previously another Dean Cadillac for 10+ years, An Epiphone Les Paul Classic for a bit
Statement: Heavy &^$%%$# Metal :headbang:
Bass: Moderate bass, very very tight, that "Chunks" and crunches great. The go to for down tuning without mud.
Mids: A lot of mids that punch you in the face and cut through a mix. The cut through like a machete, a jagged sharp machete.
Highs: Screaming, cutting ceramic highs, that are honestly very similar / the same as the Custom.
Output: Hot Hot Hot, but cleans up surprisingly well with volume. Cleans, while somewhat "sterile" are surprisingly good.
Music: Dokken, Judas Priest, early Crue (Shout), Metallica (pre-black)
Guitars: #1 1979 Les Paul for 30+ years, Dean Silverburst Caddy, Jackson DX10, (and likely my other two JS32 Jacksons...or a very similar pickup....)
If I am playing had crunching definitive heavy metal, hitting the bass on the amp, and rocking had all around, or using a darker/muddy guitar, I like the Distortion.
If I am playing all kinds of music, but mostly loud and proud, but may want to mellow a bit, or have a more bass friendly guitar, I like the Custom.