It's really going to come down to the sound you're looking for out of your guitar and pedals and amp. Impossible to tell you exactly what to do. I'm guessing that you're running guitar into DS1, into Behringer distortion as a main distorted tone, into clean-ish amp, with the Zoom in the loop? And the DS1 is for a solo boost?
If that's the case I would check out the clean sound with the pedals off and the amp EQ knobs at noon; dial those in to taste; then turn on the Behringer and set your gain and EQ so it sounds right into the clean settings on your amp; set the DS1 with volume up, distortion down, and tone around noon, see what that sounds like into the Behringer, adjust to taste. If you need to use the amp EQ to dial in the distorted sound after you've done all that, use it sparingly. I wouldn't use an EQ in the loop for tone shaping - I would use it for room adjustments, like if you're playing somewhere and your amp is boomy, you can cut some lows, that kind of thing. Again something to use sparingly. Whatever comes last is going to set the overall flavor of your tone.
Also make sure that whenever you're tweaking your sound, you take some breaks and dial things in with fresh ears, in the context of whatever band mix you're working with. It's really easy to just play for a few minutes and tweak some stuff and play for a bit more and tweak a bit more and wind up completely off the reservation without even realizing it.