(Warning: long post) I had some questions about how to be more of a "traditional" or "old school" guitar player.  I was doing some experimenting tonight....
Usually I have my guitar's volume and tone knobs at 10.  Let's use the Stratocaster as an example.  Mine's a Lite Ash, so the tone knobs are neck and middle, with bridge being totally without a tone knob.  Three true single coils.
I plug into a Boss ME-50 and then into a Fender Pro Junior.  Usually the Pro Junior's tone knob is at "12 o'clock" and the Volume is moved to match.  The Boss ME-50 knobs for Level are always at "12 o'clock" or lower, and the main output is at "12 o'clock".  I did this for the recording session we had, playing around, and when I heard it played back, it sounded WAY too generic for me.  Either that or too familiar.
Tonight I tried something totally different.  I'm wanting to be more of a "traditional" guitar player, since those guys (Slash being one of the last, at least in my uneducated opinion) get great tone.  I set volume and tone knobs on my Strat at all 5's, set the amp volume to a decent level and the tone on the amp until the bridge was almost unbearably bright (but works good for solos ala Boss OD-2 Turbo Overdrive setting).  Now, from the guitar, I can increase and decrease neck and middle pickup brightness using the tone knobs, and I have louder and softer using the volume knob on my guitar.  Then I pick what distortion or overdrive, tremolo, etc, on the ME-50 based on the voicing of it, not how loud it is.
I was much happier this way.  My tone no longer sounded generic, but more "customized."
So my question is: is that the right way to do it?  I've never thought to ask how to set amp and guitar knobs before: usually I set 'em all to "12 o'clock" or 50% on the amp and all max on my guitar.  How do I become a more traditional player?  How do/did those guys get such a unique sound on their rigs?  (aside from fingers themselves).  This is not a "it's all in the fingers" thread, as I'm leaving that out of the equation for right now.  I'm focusing on guitar and amps.  How should I do things?  How do I get more mojo?