I'm glad someone gets this concept... in most bands I've been in, I've been the lead or only guitarist and over the years I've developed a number of techniques to aid in that. Technique IS a big one that gets overlooked. Just playing clean, clear notes that are in tune and having a solid picking hand can do awesome things to your sound. 
Other things that help.
- Strings that are as heavy as you can get without adversely affecting performance. I use .010-.052. 
- Back off the gain, bump the mids up, and go for more volume instead of more gain. You'll get a fuller, clearer sound. 
- making sure the instrument is set up right for pickup height. 
- making sure your caps and pots aren't thinning out your sound. 
- Good speakers that transmit a nice full range of tones, not just concentrated in one frequency. 
As far as the pedal from goes, I'd go for an EQ pedal or some sort of boost or drive pedal with EQ options. I just picked up a BB Preamp and I'm loving what it does for my sound. Great bass response and just enough compression to fatten things up nicely.