Although I much prefer to search for people asking about the Full Shred ... I contribute.
I've used the Trembucker Full Shred in Alder and Poplar bodied guitars for about 5 years now. It's been run on various different amps and always using 500k volume pots.
I'll try and sum this up easily
Voice: The Full Shred is a very distinct sounding pickup that is very articulate and can easily cut through the mix. Similar to single coil pickups, the articulate nature of the pickup means that string to string picking and runs are clear even under a considerate amount of distortion. Sweep Picking, and Palm Muting are areas where the Full Shred excells. With palm muting, the articulation means that the Full Shred delivers pure "Chunk". Being high output and also having the articulate (you gotta hate this word now) nature of this pickup, I feel it is compressed sounding ... especially clean ... hence why I also use the '59 in the neck.
EQ: The EQ (which I feel is slightly different to voice) is more focused on the upper mids and highs, lows are not boosted that much, but unlike other pickups that I have tried, the bass is extremely tight once you learn to get it out of there.
Common Complaints Some people complain that the Full Shred is harsh, too bright, or doesn't have enough bass ... all of these from my experience can be fixed. The bright and harsh impressions are often from people not re-adjusting their EQ, or the pickup height (important). Generally, taking the time to experiment with these will result in you getting a better feel for the pickup. Not having enough bass ... sometimes I feel the same but I've found some solutions which will be answered in the next section ...
How to get the most from your Full Shred Woods: I prefer it in Poplar ... and I think it'll also be good in Mahognay and other darker woods ... this will help increase the bass responce in the Full Shred. Albeit, Farkus, much to my hestitation over his choice uses it in an Ash guitar and seems to be pleased with the results.
Amps: Closed Backs! Tight Tight Punchy Bass will occur when you mate the right guitar and amp with the Full Shred and a Closed back cab. Once again, play with the EQ and (suprise) the gain settings ...
There's all sorts of things you can do ...
DYK info ... Mr. Betts from the Allman Bros. Band is listed as using the Full Shred in the bridge, and is not a one trick pony, I also use it for Classic Rock, Bluesgrass, Alternative, Blues, Fusion, and other experimental styles of music.