IMO yes, enough of a difference to be well worth consideration.
I've found the contrast between polished and rough A5s to be pretty minimal, limited only to the high treble - a little less sparkle, perhaps a subtle hint of graininess.
UA5 however has a personality distinctly different from A5. Warm-yet-crisp highs and richer mids. Lows are balanced but less punchy, perhaps not quite as deep. A more vintage voicing with a slightly looser feel overall. Its attack is altered too - less aggressive. Sometimes described as having a bit of A2 in its character.
I've found UA5 to be perfect for my taste in several different bridge pickups.