Re: Screamin demon
This largely depends on what kind of flavor you want in the neck and middle positions. If you want a setup that would give you strat-like tones then sticking to true single coils would be your best bet (and not something I have enough experience with to really help out with). In the single-sized buckers, though, I used to run a Demon with a Cool Rails (neck) and Vintage Rails (middle) that was a very nice set - one I regret unloading. It was a well rounded pickup set that tonally covered a ton of ground. That said, it didn't have a typical "strat" single coil sound to it, not even in the notch positions.
In my experience, you couldn't make the Screamin Demon muddy with a bucket of dirt and a gallon of water. I had success running the Demon in a Les Paul with 300K pots and the low end was quite tight. Therefore I think personal taste and the other pickup choices are the best way to decide what pots to use. I wouldn't automatically rule one value out because convention says so.