Separate Pre-amps

Hi-diddely-o o good folks on the forum!

Long time no post.. comp problems :gurmpy:

Anyways, I've been explring the world of guitars and amplification a bit further still, and noticed that quite a few artists use separate preamps in their rigs..

My own amp, A carvin XT-112, is a nice tool, but sometimes I want to go OTT with in-your-face-and-out-your-backside-brutal distortion..

Can you people recommend any neat more-or-less tube preamps for that purpose?

Also, on a more general level, list all the down and upsides of using separate pre-and power amps. And can a pre-amp be used like
Guitar -> preamp -> effect return
or will I blow up my amp?
 
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