So, would it be an unwise decision to rig up an A/B box to the two inputs on the Vox Valvetronix so I can bounce between the Low and High Inputs without needed to unplug anything?
The A/B box should keep the unused output isolated well enough that there's shouldn't be a problem with it. That's a great idea actually. My AD50VT only has 1 input so I just make do. I do have one pedal I like to use with my Strat and turn that on when in use. It works well with the acoustic too. It's just a buffer/booster.