Hmm...I've got the volume pot wired like this:
http://www.seymourduncan.com/website/support/schematics/sgl_coil_1vol.html
...with a treble bleed capacitor between the right and center lugs.
The reason I ask is for 2 reasons. The first reason has to do with the general difference between 500k and 250k on the sound. I've got a 250k no-load pot in my single-coil strat right now. When I open it up, there is a huge difference in ouput and presence (both highs and lows). I was wondering if it might make more sense to have a 500k pot in there, so I can have a smoother transition from 250k to a higher resistance (yeah, I know that 10 technically has not resistance on a no-load pot). However, it sounds to me like you're saying that a 500k pot set to 250k will have a 500k load, and therefore sound different from a 250k pot at 250k.
Secondly, I had wired up a pickguard (this with humbuckers) to experiment with treble bleed circuits. I had aligator clips hanging out of the pickguard so I could experiment with caps and resistors externally. I also had a push-pull pot set up so I could switch between the conventional .001 circuit and the experimental one.
It's no surprise that when I had no bypass circuit connected, the 250k setting was not as loud and sounded more muffled than the 500k setting. But what really concerned me was the effect of the treble bleed circuit. At 500k, I noticed little or no difference between different circuit designs, or whether a treble bleed circuit was connected or not. However, rolled back to 250k I could notice quite a difference (which is what I expected). So, going from this logic to a strat with a 250k volume control...does a treble bleed circuit have an effect on the tone, even when the volume is wide open (250k), like it does when using a 500k rolled back to 250k?