You've gotta get it sounding GREAT in the room... then deal with mic positions. Remember that moving the SM57 literally a centimeter will change the tone - don't be surprised if you spend an hour moving the thing, tracking, moving it again, tracking again, etc...
Vox... just don't just an SM57

. I've not found them to work on anything but growls/screams, and even then, I prefer a nice dynamic like an SM7 or a condensor.
Cubase/Nuendo are virtually the same DAWs, granted you match the numbers up.