Re: Do mic isolation shields work?
Ah, ok, I missed where you said it was a desktop. I had that issue with a laptop, which is why I asked. The interface kept turning on the built-in webcam mic so I kept hearing fan noise and the "plinky plink" of the guitar and it took forever to figure it out. Had to plug a dummy cable into the mic jack to make it stop.
The cabinet may be acting like a band shell, amplifying the fan noise, similar to how touching the head of your bass to the wall turns the wall into an amplifier.
If the desktop does not truly need to have all 3 fans running, disable 2, leaving only the fan directly on top of the CPU itself, at least when recording. If overheating is a real threat, remove the side panel and just use the CPU fan, and turn the open side of the case away from reflective surfaces, or point it at an isolation panel.