Re: 2 or 3 Humbucker Tele?
I can only speak to having 3 mini-humbuckers. My Firebird has 3 vintage mini-humbuckers, and wired the Gibson way, it sounds a bit like the bridge/middle setting of a Strat; it actually has a slight twang to it for a Gibson but certainly not the twang of Strat. With bridge/middle together it loses a little bite on the top end compared to bridge alone, some warm bass comes in, but the combination still has strong enough mids to drive distortion in an amp. It's a complex sound, hard to describe, but I have found it useful as a middle tone between bridge and neck. With the 3-PUP wiring, the transition from bridge to neck is less dramatic to my ears.
When I bought my Firebird, someone had done a Rickenbacker wiring where the middle pickup was wired to it's own volume, and at that time it had modern overwound mini-HBs. With that wiring I had to mix the middle with the outside bridge and neck PUPs. That wiring sounded different to me, possibly from the extra volume control in the mix. The middle pickup made everything sound darker until all the way up, then it was bright and fat, without any kind of twang.
Sorry I don't have experience with 3 full-size HBs, so I don't know if that helps.