the first time I ever saw a Sub Sonic Strat it was in a little shop used and they had no idea what it was, it had light top heavy bottom strings (10-52) and it was tuned to e standard...it was a little on the tight side but you could do it...
Murder by death, how are ya? it may work but, that would probally be a whole lot of tension on the neck. I have never tried it so I dont know if it would be a great idea or not.