It is always going to depend. As soon as your amp is not operating on the linear part of the curve, you will start to get distortion on the Negative and Positive halves of the wave.Just out of curiosity when you bias the an amp hotter, does it give you more volume? or does it mean that the power tubes break up at lower volume?
You are so much better off just biasing for the correct bias rather than trying to push it hotter. The new tubes themselves should help your problems. A hotter bias wont fix what you are trying to do.
In many ways you are fighting against what a 5150 is and does. trying to make one more marshallesque is like trying to make a les paul into a strat.
new tubes should help some with the fizziness, keep in mind the preamp design on the 5150 is fizzy by nature so you can improve it but it will always be there to some degree.
get the new tubes in it and biased correctly, get a decent cab... then go from there.
Its a 6534+ i use it once a year and want to get a year out of the 6ca7 tubes that are being put in, and for the power tubes to break up around 3-4 on the volume, thats the current volume i run but the amp sounds cold and horrid, im hoping if its biased hotter i get a more tube character at that same volume maybe a little more marshal-esque and less ice picky...
Once a year? Correct me if I'm wrong but...from what I understand tubes can go bad by just sitting in a amp for extended periods of time.