I am mostly a high gain shredder and I have developed a personal relationship with the truss rod in each of my guitars. You can usually find the best compromise between relief and bridge height to give the best action overall, but there are certain places on the neck that need to breathe more. Notably, the notes 12+ on the higher strings. If the action is too low, they will pinch out, even if there is no discernable buzz.
I believe you should set the action so that the most important areas of the neck have no buzz. For instance, if you find that the higher frets are pinching out, you can straighten the neck and raise the bridge on the treble side, this will give better action on the high frets, but might create some buzz around fret 5. For this same guitar, you might find that you don't have to raise the bass side of the bridge - there may be some pinching on the higher frets, bass side, but this doesn't matter above fret 15.
ALSO, make sure your bridge has the same profile as the neck, you may need some floyd saddle shims.