The rig I use as my home practice setup is the Vox AD60 head into a straight Marshall Jubilee cab. The Matchless sits next to it. I tend to use the Valvetronix for gainy tones and soloing, while I use the Chieftain for playing clean.
I'm assuming that the floorboard is the same as all of their amps...with a few extra features. What I like about the Tonelab SE is that it can be used as your home rig or live rig, depending on what amp it's fed into. I like the Vox stuff because the high gain tones feel like a real tube amp under your fingers....moreso than the Line 6 and Cybertwin. Of course, it's hard to compare gear......just buy it at GC, use it for a couple weeks and either return it or keep it. Gotta love that return policy!