I've got one in the bridge position of my Tele (with a Duncan Classic Strat Stack in the middle, and a Lace Tele neck pickup in the neck.)
I love this thing in the bridge with one caveat...I wouldn't use it without a series/parallel switch. While the series tone is a great one trick pony, the parallel tone gets it back into Fender territory.
The series tone is a GREAT distortion tone, being wonderfully voiced and focused. All distortions, be they amp or effect are driven great with the HR. But it is very high output and the clean tone is limited. Mixed with the other pickups, the output is tamed. In parallel though, the output drops to match well with the other pickups and it becomes clear and fairly bright...though not ever strident.
To wire this pickup in without series/parallel capability is to miss out on half of it's potential.