I've had success with various modelers and amps to cover the 5150 part (Fractal FM3 into a 2x12, Fender Mustang, Crate GTD, VST plugins), and have used a variety of boosts as well - really any pedal with a gain control has worked pretty well. Latest go-to for this tone is just dialing in a boost within the Fractal FM3 but it all gets me the same flavor whether I'm staying within the FM3 or using the gain control on a flat EQ pedal to boost into a physical amp. I think the type of boost is less important than getting amp part right. The MXR pedal is probably a good place to start for single use pedals. However personally I'm a big fan of the digital stuff because there's always been an option that works for me in those boxes, so if you could pony up for something like an HX Stomp you're pretty much guaranteed to find a way to integrate this sound into your setup (with some solid reading/tweaking/experimenting of course). If you did that, since you don't like analog drives into simulated pres, you could put the HX Stomp at the beginning of your chain and dial in the complete boosted 5150 tone within the unit and only engage it when you want that sound. Just thinking out loud.