Re: change Strat config to just 1 humbucker
I'm doing the exactly same thing myself! So from my experience, I'd say probably the most important thing is whether your guitar is correctly routed to take a humbucker.
When you lift off your existing scratchplate, you may be unluckly enough to find that there are three cavities in there that your stock single coils slot nicely into. This is BAD. What you want is either a guitar that's designed to accomodate humbuckers in the neck and bridge position. this is characterised by large rectangular holes with even deeper holes either side for the screws to go into. Ideally, you may even have "swimming pool" routing, which is essentially a large rectangular hole with screw groves going the whole way along either side. This will allow for almost any configuration of pickups.
Another potential issue is that your replacement scratchplate's screwholes may not be lined up to the holes in your strat (esp. if its a squier) but this can be remedied if you're willing to improvise.
But 1 humbucker strats are extremely easy to wire. You basically just connect it to the volume pot, then connect that to the output, then ground everything. You'll need to sort out the seperate wires inside the humbucker's cable to configure it, but this is fully explained on the website.
If you're doing this yourself, don't hesitate to ask questions if you're not sure about something. Good luck!