The thing is that such single coils owe their output to a higher inductance. So they're louder but also darker voiced than regular Strat SC's, because of a way lower pitched resonant peak. Reason why they won't deliver the typical 2d or 4th positions tone: they will sound thicker.
It's not necessarily a bad thing: the Strat copy that I've used for my first big concert, more than four decades ago, had 3 beefy single coils, closer to P90's than to Strat single coils: I've recently brougth them back from the grave and measured them @ 6.07 to 6.17H (it's 3 times the inductance of a CS69, for the record; a typical P90 clocks between 6 and 7H). Their sound was... "muscular". It just lacked that Strat sparkle....
Later I've mounted a SSL5 (measured inductance: 6.19H) in my first home made Strat. Still too middy to my ears. Finally traded it for a dead Kahler trem that I've repaired...
It's possible to obtain more brightness from such beefy SC's, by putting a LR filter (resistor in series with an inductor) in parallel with them. But it will lower their output.... Now, it's this solution that I'd probably use for
realistic 2d or 4th positions with strong PU's: I'd mount a super switch enabling a custom voiced LR filter in parallel with pickups in positions 2 and 4 only.
It's conversely possible to obtain the voicing of a SSL5 from a regular Strat PU, by putting it in parallel with a 1nF cap to ground. But it won't have the same output, of course...
FWIW: more tedious rambling from an old fart.
Happy new year, fellow members!