Like Jeremy said, you can use the 4 ohm out, it will be close enough (5.3 ohms for those keeping score) but the 8 ohm cab will get twice as much power as the 16 ohm cab.
The 8ohm cab goes into the 4ohm output, this is 1/2 load for the output transformer. The 16ohm cab goes into one of the 8ohm outputs, another 1/2 load. Gives you the right impedance match. This is how I'm running my DSL40CR with the internal speaker into the 8ohm output and the external 2x12 8ohm cab into the 4ohm output. It's well documented on marshallforum. https://www.marshallforum.com/threads/two-cabs-of-different-impedance.101563/
The 8ohm cab goes into the 4ohm output, this is 1/2 load for the output transformer. The 16ohm cab goes into one of the 8ohm outputs, another 1/2 load. Gives you the right impedance match. This is how I'm running my DSL40CR with the internal speaker into the 8ohm output and the external 2x12 8ohm cab into the 4ohm output. It's well documented on marshallforum. https://www.marshallforum.com/threads/two-cabs-of-different-impedance.101563/
That's also how it's suggested in all my Mesa manuals; 4ohm output to 8ohm cab,,,,,,and 8ohm output to 16ohm cab.
Running as such you can expect a slightly darker tone and softer attack than you would get running an evenly matched setup. (if all the settings were exactly the same both ways)
The 8ohm cab goes into the 4ohm output, this is 1/2 load for the output transformer. The 16ohm cab goes into one of the 8ohm outputs, another 1/2 load. Gives you the right impedance match. This is how I'm running my DSL40CR with the internal speaker into the 8ohm output and the external 2x12 8ohm cab into the 4ohm output. It's well documented on marshallforum. https://www.marshallforum.com/thread...edance.101563/
You need to read the rest of the thread, supposedly that only works on the JVM (and I have questions about how they are using multiple taps off the transformer). Running both cabs in parallel off the 4 ohm tap will be fine, the power will just be unevenly distributed, 5.3 is close enough to 4.
Mincer Mesas are fine with mismatched impedances, but that is different than using multiple taps off the output transformer. Some Fender heads just had High, Medium, and Low instead of actual impedances on the speaker out settings.