If you figure that a Gibson 335 has about $300 of pickups & hardware (at retail), that leaves you with a couple grand worth of wood & frets. If you have the money go for it. The quality of raw materials & workmanship is a little better, but you is it that much better?
I have a black Epi Sheraton that I installed a '59N & Custom 5 in, and it sounds great; I'd put it up against any Gibson 335, and bet that 99 out 0f 100 players couldn't tell it from a Gibson blindfolded. To me, this really makes sense. Get a used, like-new Sheraton for $300 to 400, put in a couple of good American-made pickups, and you save a bundle. For live gigs, you aren't out a fortune if its banged up or stolen.
Another viable option is a Japanese-made Epi Elitist 335 or Sheraton, which rival Gibson for quality, and are priced in between the Gibsons & regular Epi's.
If you want to spend 2,000 or 3,000 regardless, you can get an Epi Elite & a couple Sheratons with Duncans (each with a different combination of pickups, like one with PAF's, and another with a hot bridge), for what one Gibson 335 will cost you. To me, there is no other way to go. But then, I'm a working man.