The set ups were never the same song to song...thats why I didn't list a specific set up or get into the "let's split hairs about Ed's pickup" game...
A Fender style guitar with a bucker in it through a cranked amp that wiht a closed back Greenback cab will get you close...
A lot of Ed's early sound was for sure VOLUME...I for one don't think you have to have a lot of volume to get a good sound but there are some sounds out there....The Brown Sound, Cream era Clapton, early ZZ Top, etc that you will never nail unless you can crank a fairly large amp...sorry...