Overall, my setups have been the same for a very long time. In some instances I like very minimal relief and on other cases (guitar build types) I like flat. Low action without detectable buzzing amplified or that alters string ring.There is that fine line in getting it right so that it is low and doesn't alter anything or hinder anything I may do playing wise or technique wise.
String wise, I have primarily been an 11-50 in standard tuning and at times done the 10-52 thing. I recently started messing a bit with different gauges and sets (brands) and have stumbled on a few things I really like. I learned (Thanks Rick Beato) that the thicker strings may be counter productive to what I am doing. After spending some time, I have to agree it was. So I am expecting 10-48's to replace the 11-50's and the 9-46's to replace others on cleaner, swankier type sounds (think tele). By going down a tad in size I found things to be a bit more articulate without losing anything "heavy sounding" which I thought I would lose. In actuality, it tightened things up and made them more focused. Things are more consistent now and I don't have to work as hard. It has been an interesting process.