It might be my imagination, but I hear a slight difference between hum canceling singles and true singles, especially stacked hum canceling singles. Something about them kills the highs, dynamics, and transients a bit vs. a true single coil.
I might also prefer 2 true singles instead of RWRP to cancel hum so it's more vintage authentic.
My guess is the Jackson singles will be hum canceling, as many singles seem to be these days. To me those sound more like humbuckers in a single coil housing.
I'm weird for a metal guy in that I like a pretty mid output bridge pickup (say 12-14k) but I almost always insist on the lowest wind singles I can find--usually 50s spec. I find you get more of that Mark Knopfler spanky Strat sound that way. The real choice is whether you want a bright Strat or a warm Strat--so I have a lot of HSS Dinkys so I can have bright/warm Strats.
I would only go up in single coil output if you have something hot in the bridge like a JB (around 16k) and want output levels matched.
Since I mainly only record, it doesn't bother me to have mismatched pickups in terms of volume. It's just important that the instrument makes the sounds I want.
Very, very rarely will I go for high output pickups in both positions. I don't solo with a hot neck pickup much, but I'm working on a guitar with a JB in the neck and Dimebucker in the bridge. I'll save something like a Duncan Distortion or Parallel Axis (16k+ output) for guitars I exclusively track solos with because they cut through well and compress without sounding squashed.