that's funny...i was just wondering about a similar but opposite thing. i wondered if anyone buys a combo and bypasses the guts to just use it as a speaker cabinet when the need arises. given the cost of some extension cabs, it would seem an economic benefit to use a combo as a cabinet.
as far as your question goes....i'm sure that's an easy deal. i would think you could even just cut into the wires leading to the speaker and insert a male and female jack there. of course, that would bypass the internal speaker, but given ohms issues with amps, that might be a good thing. many combos don't seem to have an ohms switch, and can only handle certain ohmages on top of the internal speaker. with a tube amp, you'd really have to watch it cause it would fry quicker than a ss amp i think if you didn't have the ohms set right. also, i think there may be volume issues when you start adding cabs without the ability to change the ohms.