Re: Im no bonamassa, but....
For me, at times, the rhythm guitar was getting in the way of the lead guitar. I would either reduce the level of the rhythm guitar in the mix, soften its high end frequencies or rethink the part. e.g. When the lead guitar is playing a lot of 16th and 32nd notes, the rhythm guitar could get away with being a simple, sustained chord for the entire bar. Alternatively, most of what the rhythm guitar provides could be implied by a well thought out bass guitar part. (Think Willie Dixon, Tommy Shannon, Dusty Hill.)