Re: Jackson J50b and J200 replacement
If you don't want rails at all, I'd look at an STK-S6 Custom Stack Plus in the neck, in addition to the STK-S4 or STK-S7 in the middle.
The reason for the lower output middle is that gives you the best quack in the 2+4 positions.
Stack Plus series are much more single coil sounding, if that's the sound you want. A brief summary of the different ones I've suggested:
STK-S4 Classic Stack Plus is a noise-cancelling version of the SSL-2 Vintage Flat (which is the flat radius version of the SSL-1 Vintage Staggered). Classic Seymour Duncan single coil, used by a ridiculous number of artists.
STK-S7 Hot Vintage Stack Plus is a moderately overwound vintage single, that doesn't have an equivalent in Seymour Duncan's non-humcancelling lineup. Similar to the sort of overwound vintage singles a lot of SRV tone chasers use if they don't like gargantuan strings.
The STK-S6 Custom Stack Plus is a noise-cancelling take on the SSL-6 (which is a flat radius version of the SSL-5 Custom Staggered) Custom Flat which is a hotter wound single coil that David Gilmour sometimes used for a bridge pickup. Hotter and more midrange, still sounds like a single coil but behaves better under high gain than most low output singles.
The rails do give a pretty different tone, a side-by-side humbucker, but with narrow coils and a tighter focus. Humbuckerish tone with a single coil-like punch.
The PATB-2's looks might not work for you, if you are hung up on classic looks. Still, there's nothing quite like it in the conventional TB lineup. Riffs like an Invader, but it's not as dark. Thrash rhythms like a Distortion, but not quite as harsh a presence. Screaming leads almost like a JB, but it's thicker, way hotter and more compressed.
The TB-6 Distortion's not as thick and more biting. Still the same family of sounds as the PATB-2, but thinner and harsher. Slightly better for biting thrash rhythms, but gives up a bit on riffs and solos. If your guitar is dark or bass-heavy, it's probably the better choice.