Re: Line 6 amp cleans + OD/Distortion pedals?
No. OD's usually sound their worst plugged into a clean SS amp. Usually the worst tones that modeling amps make are the midgain tone. They usually do clean and highgain very well, but lack the complexity needed for good medium gain tones.
For all shades of gain, modeling amps sound best when you use their built in gain and pedal models.