I think if you were blindfolded, sitting in front of my amp, you'd be hard-pressed to hear differences between my Gibson ES-335s and my LP Elegant. The Elegant is a chambered model; both feature '57 Classics.
And the same is true for my Antiquity-equipped 335, and my 1960 Classic Premium Plus, also with Ants. The Classic is a 1997 model, and is weight-relieved.
Feel-wise, the 335s seem to have a softer attack, but it's real subtle.
I use them interchangeably. But I have other Les Pauls with different pickups, and they do sound different.
So what differences do YOU hear, and what are you trying to accomplish?
Bill