More about KT66s if your interested. The KT66 dates to the 1930s. It was quite a bit more tube than the 6L6 of the times. It could handle up to 550 volts on both the plates and the screens. The plate dissipation was 25 watts. The first RCA 6L6s had a plate dissipation of 19 watts and handled less than 400 volts on the plates and screens. The 5881 handled 400 volts on the plates and had 23 watt plate dissipation.
The first JTM45s used American 5881s but Marshall switched over to the home grown KT66s after a short time and most JTM45 originally came loaded with KT66s. It is the original Marshall sound. The first 100 watt Marshall plexis, or JTM45/100s, operated at high plate voltages, so KT66s were a must. Marshall switched over to EL34s during 1967 because the supply of KT66s was not great. Probably started costing too much. The EL34 of course established a great sound of its own. And speakers were probably more important to the tone anyway.
5881s and 6L6GCs are not a direct substitute for KT66s. There is really no direct substitute for a KT66. The KT66 has its own sound and other tubes with high voltage ratings such as the EL34, and 6550, and KT88 sound different.
The Vintage Modern 100 watt runs high plate voltages being based on the JTM45/100, so 5881s should not be used as substitute. 6L6GC would be at their limit in a 2466, but they don't sound exactly like KT66s. KT66s sound as huge as they look.
This is an overview of modern KT66 options:
https://www.thetubestore.com/kt66-tube-review