FWIW I tried putting a standard Strat pickup in the Tele neck hole and it was too long and the screw holes didn't line up with those in the pickguard - by just enough to be annoyingly close to the standard Tele ones too.  Not enough real estate to dill new ones without getting too close, possibly overlapping the original ones.
Shame really, because I quite fancied Little 59s in the bridge and neck.