Re: Real Amp vs VST amps.
I have an IRT Studio that I don't use since I got Helix Native. With a good interface, once you get used to the cab modelling quirks [they don't filter the fizz as thoroughly as most competitors, so you have to drop an EQ block after the cabinets, or EQ more aggressively in the cab model], it's amazing.
The cab/mic simulation is very good, with a good variety of cabinets/mics and with mic placement, you can duplicate studio sounds obtained by mic placement rather than trying to get there with post EQ. I've wound up scouring producer & engineer interviews for information about what mics and placements they used on different recordings, not something I paid this much attention to before...
IRT Studio is pretty nice, I found the boost a bit noisy, and had trouble balancing clean tone vs rhythm, as the mid gain tone I use I want rather different EQ from than my clean tone. That aside, it at least only has shared EQ between clean & rhythm, with totally separate EQ on lead channel. I pretty much exclusively used the 1W mode, since my Mesa Thiele EV12L was too loud for bedroom use at 15W.
For home studio use, Helix Native is just awesome. Covers most of the common effects, great variety of well-modelled amps, good amount of deep dive tweaking capabilities [like ripple/hum in modelled power amp stages, which a lot of metal players may prefer to completely kill, where vintage amp fans may prefer the realistic behavior]. It supports 128 user Impulse Responses [IR] if you prefer searching IRs rather than tweaking cab sim settings.
The Litigator model is amazing. I've been messing with different speaker pairings. Deluxe 1x12 with SM57 and 2xC12Q with R121 is great for a smooth Fendery place with an interesting grit on chords, but a pair of 4x12s, G12H30 with SM57 and G12M20 with R121, is nice to push it to a fat Bassman/Marshall territory.
One of the few factory patches that took little tweaking to make work with my guitar was 'Pick Attack Solo'. Single coil, enable the univibe and Industrial Fuzz [oscillator on] for instant Hendrix Star Spangled Banner tone. Ridiculously fun. Noisy, sputtery wailing madness with self-oscillating fuzz mimicry of guitar feedback tones.
And Line 6 is doing free updates, IIRC 7 amps and 7 effects dropping before the end of the month, plus new UI and engine improvements.