For me, it comes down to the playing experience, and I'm not sure if you could tell the difference just by listening. I love my Areas and have no doubt that the Duncan offerings are awesome. Fender Hots and Noiseless can sound great as well. But every noiseless I've played feels like I'm only playing/manipulating a narrow, carefully tuned band of the spectrum, almost like they are manicured with high/low cuts on an EQ or something.
A good single coil feels like you're playing the whole sound, from the lowest lows to the highest highs. It gives you the good, bad, ugly, and beautiful. Sometimes I don't want the hum, but when I go back to SSL-1s, APS, etc., it feels like they invite me to dig in a bit, play differently, and really sculpt the sound using my pick.
That's the best way I can explain it.
Edit: To be clear, that difference is enough to me to make it worthwhile to own guitars outfitted both ways. And I dig many humbuckers split, too--it's all food for the muse.