For traditional strat tones, you have some great recommendations going here... So I'll give you an alternate direction.
I would suggest little 59 in the bridge with a DiMarzio cruiser in the middle and a cool rail in the neck. These are all relatively warm pickups and as mentioned before... the 59 won't give you a single coil out of the box, but the cool rail and the cruiser will give you nice modern single tones.
You definitely can get some good quack in the four position, and I can't remember, but you might get some quack in the two position.
But here's where it gets fun... Add either a spin a split or parallel to self and all of these pickups get snappier, stratier... The cruiser and the cool rail can almost give you a classic strat tone.
Advantage of the spin a split is you really can spin them down to a single coil depending on the noise in the room.
Advantage of the parallel is you'll never get the complete single coil sound of a spin a split, but it will remain humbucking and you get some really good stratish tones that might even be more useful than a single coil tone.
Spin a split and parallels are very simple circuits if you've not done mods in the past, they're pretty easy.
Sounds like a fun build can't wait to hear more.