Re: Single pickup guitar owners, have you noticed this tone difference?
For my purposes, I don't need scientifically-identical strums to determine if I'm getting a different response from a pickup and guitar. I play the way I play, after 35 years and playing some songs thousands of times, and humans being creatures of habit, I will hit the guitar with reasonable enough consistency for my purposes to tell if something is different between two guitars or two pickups. While we tout the flaws in humans as some unrepeatable unique character that AI cannot yet replicate, we also underestimate and undervalue the ability of humans to perform consistently after a great deal of practice and repetition.
I don't have a strong view on modelers and any detail loss. What I can comment on is I know my hands and I know my guitars and whether I plug into an amp or a modeler, both lose something or change something (usually in good ways) when compared to the original direct signal off the guitar. I can work with either well enough to ascertain if I'm getting more bass or high end when playing near the neck of a single-pickup guitar. I think either an amp or modeler would be a fair test. Using several of both alternately would be an even better comparison, which is what I tend to do. I will use a SansAmp PSA-1, a Line 6 Flextone, an Orange AD50, a Marshall JTM45 (clone), a Fender Champion, etc. comparing all. Somewhere between all that comparing I start to get to know what portion is the amp, what portion is the guitar and what portion is my hands at work.
Anyway, I'll pull the neck pup out of my Tele later and see what happens. I think this is a good and interesting discussion.