it depends on the pickup really, especially with scatter wound ones - every pickup has it's own custom uniquness so you have to play with the height gradually until your ears find the magic...
if you're talking about slanting the pickup so one side is closer to the bridge, then I do actually do that with my bridge pickup so it's closer to the bridge at the treble side. my pickups on my custom Warmoth are:
Humbucker, x, Angled Humbucker
looks really cool and unique as I've never seen anyone do that before, but it's more than perfect for me