Just something about how your hand just settles in around the headstock of a strat. Very rounded and smooth. The V-neck thing helps that feeling out a bit.
I really want to try out a guitar that has a V neck profile. I've been paying a lot of attention to how my fretting hand grips the neck lately and I have a feeling I'd find it really comfortable.
ah, but ergonomic-wise Strats have nothing on a Steinberger or a Klein. In fact, if guitars were built from purely an ergonomic standpoint, most guitarists wouldn't play them. Check out the Ergonomic Guitar site here.