Re: Stripping...
Problem is that you end up with such a thick layer of paint, it's difficult (near impossible) to get anything to stick to the poly, the new coat of paint chips much easier, it takes much longer for the paint to cure.
It's not textbook ideal, but lacquer and poly
are compatible, either way (lacquer over poly or poly over lacquer).
This one that I have in progress is lacquer over poly. The lacquer went down just as nicely and sanded just as well as if I had used a lacquer sealer. And it actually dries (lacquer doesn't "cure") faster than if you had put it over lacquer. It will help the overall thickness that the original finish was actually a pretty nice and thin matte poly. You could see the imprint of the wood grain in the surface of the poly. I couldn't have applied a lacquer sealer coat any thinner than the factory poly, really. I prepared the surface with 400 dry sandpaper before priming it with a lacquer primer.
It isn't just me in my garage who does that, though. Every Fender from '63 onward that has had lacquer on it, including many present-day Custom Shop guitars, and all American Vintage Reissue Series guitars, has been lacquer over some form of plastic-like sealer ("Fullerplast").
And not even considering the Fullerplast thing, Fender did both lacquer-over-poly and poly-over-lacquer from the late '60's through CBS' sale of the company in the '80's. Lacquer was often used as a top coat on lower-end models like the Musicmaster Bass, even though the color coats were poly. And the color coats on sunbursts were sprayed in lacquer even through the '70's, though the clear coats went to poly starting in '68. So sunbursts were basically a lacquer sandwich on poly bread. Fullerplast sealer (basically poly), lacquer colors, then poly clear.
This doesn't even bring up that fact that many (most, actually) '60's custom colors were acrylic laquers, not nitrocellulose ones. So those guitars were poly sealer, acrylic color, then nitrocellulose clear. Three different types of materials on the same guitar, straight from the factory.
In a perfect world, it is of course preferable to match finish types throughout a project. But that doesn't mean that you
must do so, or that anything really bad will happen if you use both lacquer and poly coats in a paint job. In fact, if you are going for historical accuracy on a Fender paint job, you have to use both types (and sometimes three types) in many cases.
As for your questions about stripping poly, it takes many passes, and you must give the poly some sort of tooth for the stripper to latch onto. To prepare the poly to be stripped, I started at 400 grit, then worked backwards to 100 or 120, then applied the stripper. I think I took three or four days, and probably a whole quart of stripper, to strip the finish and the Fullerplast sealer off of a '70's Fender that I refinished. The key is to not be in a rush, I guess. After all the Fullerplast was finally off, I used mineral spirits and then sandpaper to clean the remnants of the stripper off, so that they didn't interfere with the refinish. I suppose acetone would work well also, if not even better. (I didn't have any at the time, so I used the mineral spirits.) This was an ash body, with ash's relatively deep and wide grains. It would probably be a little easier on alder.