I haven't noticed any problems. On one axe I have an F-spaced neck pickup that's too big and on another guitar I have a regular humbucker with an ofr bridge.
Lately I have been using regular spacing and it works fine. I am turning into one of those people who actually feels the regular sized ones have better tone than the much larger trembuckers. They won't align as perfectly as a trembucker, but I believe the regular ones sound as they should BY DESIGN.