What I was told is that the tubes should glow more on the blue side normally. If they glow only orange/yellow, there's oxygen in the tube, which indicates the vacuum likely has been compromised.
I burned through several Marshall/Tesla EL34s this way. As far as I could tell, they were biased hot and where the metal retainer made contact with the tube, the glass developed a hairline crack. (YMMV, and I'm sure some techie on the forum will flame me with better information.)