My Strat knobs are all over the place and rarely stay in one setting very long. I heard Warren Haynes say vintage Gibson pots sound better backed off a little, so keep them rolled back a little on my ‘62 LP. I also like doing the middle position, bridge on 10, neck on 7 or so thing. I roll back the bridge tone but rarely the neck on that guitar.
I usually run the volume wide open. Sometimes I back the tone off just a hair, which seems to actually increase the clarity of the top end.