It's funny to see most people here even admit that anything makes one guitar less playable than another. A couple months back there was a thread in which many posters claimed to be proficient enough to play any style on an guitar, regardless of setup, saying that for example, a bass guitar has super high action and super huge strings compared to any electric guitar, and they could play bass guitar fine, therefore they could play any electric just fine. So... LOL
I said it at the time, but I'll say it again, a good reason to have several guitars with various setups is so that you won't go out of practice with heavy strings or light strings, high action or low action. What you can do with one, you can't necessarily do with another. You have a bag of tricks for low action and another for high action, IME. For the most part, the biggest practical difference is whether or not I can reasonably bend a given string at least two steps or not. If not, I have to switch up my style quite a bit.