I'm not talking about a wireless receiver or a buffer or an amp-modeling pedal. What do you have that you have on literally all the time you're playing?
Honestly, I don't. I like the natural sound from the amp, so I occasionally alter that with pedals, but lots of the time, it is nothing between the guitar and amp.
I use a Koko Boost as an always on pedal into my Victory Sheriif 44.
The amp simply needs help to achieve decent gain.
The switchable added mids are to emulate an EMG SPC which I removed from my guitars due to hum.